Anti-Cancer Therapies that Utilize Cell Penetrating Peptides
نویسندگان
چکیده
منابع مشابه
Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents.
Cell membranes with their selective permeability play important functions in the tight control of molecular exchanges between the cytosol and the extracellular environment as the intracellular membranes do within the internal compartments. For this reason the plasma membranes often represent a challenging obstacle to the intracellular delivery of many anti-cancer molecules. The active transport...
متن کاملApplications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This r...
متن کامل[Anti-tumor efficacy of P53 with 9R cell-penetrating peptides].
To enhance the penetration of P53 into tumor cells by fusion it with the cell penetrating peptide 9R. The fusion gene of 9R-p53 was cloned into the expression vector. The fusion protein, CPPs-P53, was expressed and purified. We detected the rate of cell growth inhibition and apoptosis by MTT and Annexin-V-FITC/PI double stained method respectively for measuring its effect on tumor cells. CPPs-P...
متن کاملCell Penetrating Peptides
During the last ten years it has been observed that a number of peptides and proteins are able to penetrate the cell membrane and enter the cell. Furthermore, it has been shown that even many cargo molecules that are covalently attached to these peptides will be translocated into the cell. Peptides that show the ability to translocate through the cell membrane are usually short peptides of less...
متن کاملSystemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides.
Cell penetrating peptides (CPPs) have been developed as vehicles for payload delivery into cells in culture and in animals. However several biologic features limit their usefulness in living animals. Activatable cell penetrating peptides (ACPPs) are polycationic CPPs whose adsorption and cellular uptake are minimized by a covalently attached polyanionic inhibitory domain. Cleavage of the linker...
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ژورنال
عنوان ژورنال: Recent Patents on Anti-Cancer Drug Discovery
سال: 2010
ISSN: 1574-8928
DOI: 10.2174/157489210790936252